Background: Quality of work life (QWL) is one of the most important factors for motivating humans and improving work. As one of the main assets for a university, faculty members should have a good QWL. However, few studies have been done concerning the QWL in faculty members and there are differing results from these previous reports. Objectives: This study aimed to investigate the faculty members' QWL in the Kashan University of Medical Sciences. Materials and Methods: This cross-sectional study was conducted on 65 faculty members of the Kashan University of Medical Sciences during 2012. Faculty members were randomly selected from a list that was prepared through the Kashan University of Medical Sciences website. The data-gathering instruments consisted of two parts. The first part consisted of questions concerning demographic information, while the second part was the Walton's quality of work life questionnaire. For statistical analyses, t-tests and one-way analyses of variance were used. Results: The subjects consisted of 64.6% men, 33.8% were in the medical college, 43.1% lived in a personal house, and 43.1% were instructors. The results of the study showed that faculty members' overall QWL was 72.98 +/- 9.62. No significant differences were observed between the subjects' mean QWL with regard to place of work, scientific ranking, and living location. Conclusions: QWL has an important impact on attracting and retaining employees, thus, it is necessary to pay greater attention to the faculty members' QWL.