ANALYSIS OF ROLE OF LEPTIN IN ORAL WOUND HEALING IN DIABETIC PATIENTS

Introduction: Leptin, a 16-kDa non-glycosylated polypeptide anti-obesity hormone consisting of 146 amino acids, is a product of the obese gene. Although leptin is mainly produced by white adipose tissue, recent studies have demonstrated that leptin is also produced by placenta, stomach, skeletal muscles, brain and pituitary gland. Objectives of the study: The basic aim of this study is to analyze the role of leptin hormone in oral wound healing of diabetic patients. Methodology of the study: This study was done at Bakhtawar Amin Medical & Dental College, Multan during Jan 2018 to March 2018. The diabetic patient of both genders were considered for this study. Those patients who was suffering from any kind of oral wound was selected for this study. For this purpose we collect the data to analyze the role of leptin hormone in wound healing process. Results: The differences between the control and diabetic groups at the three measuring time periods were extremely highly significant (P = 0.000). Totally, the means of expression after 21 days were noticed by higher values than that after 14 days in both control and diabetic groups, while the means of expression after 7 days were the lowest one. Conclusion: It is concluded that leptin plays an important role in oral wound healing in normal patients as compared to diabetic patients. But it is not clear that why leptin is not helpful in diabetic patients.