A GENERAL PROCEDURE FOR ISOTOPIC (DEUTERIUM) LABELING OF NONSTEROIDAL ANTIINFLAMMATORY 2-ARYLPROPIONIC ACIDS

被引：19
|
作者：
CASTELL, JV
MARTINEZ, LA
MIRANDA, MA
TARREGA, P
机构：
[1] HOSP UNIV LA FE,CTR INVEST,AVE CAMPANAR 21,E-46009 VALENCIA,SPAIN
[2] UNIV POLITECN VALENCIA,CSIC,INST TECNOL QUIM,DEPT QUIM,E-46071 VALENCIA,SPAIN
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 01期
关键词：
2-ARYLPROPIONIC ACIDS; DEUTERIUM LABELING; PHOTOALLERGY; PHOTOCHEMISTRY;
D O I：
10.1002/jlcr.2580340113
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Alkaline treatment of nonsteroidal antiinflammatory 2-arylpropionic acids in deuterium oxide led in all cases to isotopic exchange of the proton located at the alpha-position of the side chain. Monodeuteration was observed in the case of carprofen, ibuprofen, ketoprofen, fenoprofen, flurbiprofen and naproxen. Additional exchange of one or two protons of the heterocyclic ring occurred in indoprofen, suprofen and tiaprofenic acid. The isotopic labelling survived under the conditions required to perform in vitro photoallergic studies (photolysis in non-deuterated aqueous media).
引用
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页码：93 / 100
页数：8
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