National and regional estimates of U.S. economic vulnerability to greenhouse-induced sea-level rise are produced from a sample of 30 discrete regions scattered evenly along the coastline. Scenarios that envision 50 cm, 100 cm, and 200 cm of greenhouse-induced sea-level rise are considered. They can be expected to place $39.2, $65.6, and $133.3 billion, respectively, (1989 dollars) of existing development in jeopardy through 2050, and $133.3, $308.7, and $909.4 billion through 2100. Sampling error and consideration of the uncertainty with which we currently view future greenhouse-induced sea-level rise places the 25th and 75th percentile values of expected cumulative vulnerability at $38.5 and $76.7 billion through 2050 and $132.6 and $362.4 billion through 2100. Not surprisingly, the southeast displays the largest potential vulnerability, with the northeast ranking second above both the Gulf coast and the west coast.