OSMOTIC SENSITIVITY OF THE HYPERPOLARIZATION-ACTIVATED CL- CURRENT IN MOUSE MANDIBULAR DUCT CELLS

被引：16
|
作者：
KOMWATANA, P [1 ]
DINUDOM, A [1 ]
YOUNG, JA [1 ]
COOK, DI [1 ]
机构：
[1] UNIV SYDNEY,DEPT PHYSIOL F13,SYDNEY,NSW 2006,AUSTRALIA
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 1995年 / 5卷 / 04期
关键词：
CL-; CONDUCTANCE; CLC-2; CHANNEL; DIDS; DPC; OSMOLALITY; GRANULAR DUCTS; MOUSE MANDIBULAR GLANDS;
D O I：
10.1159/000154759
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have previously shown that unstimulated mouse mandibular granular duct cells contain a hyperpolarization-activated Cl- conductance having characteristics similar to those of ClC-2 channels. We now show that exposure of the granular duct cells to hypotonic solutions inhibits the hyperpolarization-activated Cl- current whereas exposure to hypertonic solutions causes it to be transiently activated and then inhibited. Like ClC-2 channels in Xenopus oocytes, the hyperpolarization-activated Cl- current in mouse granular duct cells is sensitive to osmolality, although its response to osmolality is the reverse of that seen with ClC-2 channels, perhaps due to a difference in the mechanism by which the osmolality signal is transduced to a change in channel activity.
引用
收藏
页码：243 / 251
页数：9
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