REPEATED TREATMENT WITH IMIPRAMINE POTENTIATES COCAINE-INDUCED DOPAMINE RELEASE AND MOTOR STIMULATION

被引：35
|
作者：
ROSSETTI, ZL
DAQUILA, PS
HMAIDAN, Y
GESSA, GL
SERRA, G
机构：
[1] B.B. Brodie Department of Neurosciences, University of Cagliari
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 201卷 / 2-3期
关键词：
ANTIDEPRESSANTS; MICRODIALYSIS; COCAINE; REWARD;
D O I：
10.1016/0014-2999(91)90353-R
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The stimulatory effect of cocaine on locomotor activity and on dopamine efflux from the ventral striatum was studied in rats chronically treated with the antidepressant imipramine. Chronic imipramine (20 mg/kg per day for 3 weeks) potentiated by about 2-fold cocaine-stimulated motor activity and extracellular dopamine concentrations. The results indicate that chronic imipramine facilitates mesolimbic dopamine neurotransmission by potentiating the mechanism which is thought to mediate the rewarding effects of cocaine.
引用
收藏
页码：243 / 245
页数：3
相关论文
共 50 条
  • [1] FLUNARIZINE POTENTIATES COCAINE-INDUCED DOPAMINE RELEASE AND MOTOR STIMULATION IN RATS
    PANI, L
    KUZMIN, A
    STEFANINI, E
    GESSA, GL
    ROSSETTI, ZL
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 190 (1-2) : 223 - 227
  • [2] NIMODIPINE INHIBITS COCAINE-INDUCED DOPAMINE RELEASE AND MOTOR STIMULATION
    PANI, L
    CARBONI, S
    KUSMIN, A
    GESSA, GL
    ROSSETTI, ZL
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 176 (02) : 245 - 246
  • [3] Disulfiram stimulates dopamine release from noradrenergic terminals and potentiates cocaine-induced dopamine release in the prefrontal cortex
    Paola Devoto
    Giovanna Flore
    Pierluigi Saba
    Roberto Cadeddu
    Gian Luigi Gessa
    Psychopharmacology, 2012, 219 : 1153 - 1164
  • [4] Disulfiram stimulates dopamine release from noradrenergic terminals and potentiates cocaine-induced dopamine release in the prefrontal cortex
    Devoto, Paola
    Flore, Giovanna
    Saba, Pierluigi
    Cadeddu, Roberto
    Gessa, Gian Luigi
    PSYCHOPHARMACOLOGY, 2012, 219 (04) : 1153 - 1164
  • [5] Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine
    Schiffer, WK
    Azmoodeh, M
    Gerasimov, M
    Volkow, ND
    Fowler, JS
    Dewey, SL
    SYNAPSE, 2003, 48 (01) : 35 - 38
  • [6] GABAergic attenuation of cocaine-induced dopamine release and locomotor activity
    Dewey, SL
    Chaurasia, CS
    Chen, CE
    Volkow, ND
    Clarkson, FA
    Porter, SP
    StraughterMoore, RM
    Alexoff, DL
    Tedeschi, D
    Russo, NB
    Fowler, JS
    Brodie, JD
    SYNAPSE, 1997, 25 (04) : 393 - 398
  • [7] Ethanol administration potentiates cocaine-induced dopamine levels in the rat nucleus accumbens
    Lindholm, S
    Rosin, Å
    Dahlin, I
    Georgieva, J
    Franck, J
    BRAIN RESEARCH, 2001, 915 (02) : 176 - 184
  • [8] Does crossing over repeated treatment with the dopamine reuptake inhibitors cocaine and BTCP modify their effects on cocaine-induced locomotion?
    E. P. M. Prinssen
    Wouter Koek
    Jacques Vignon
    Jean-Marc Kamenka
    Mark S. Kleven
    Psychopharmacology, 1999, 143 : 8 - 14
  • [9] COCAINE-INDUCED RELEASE OF DOPAMINE IN THE NUCLEUS-ACCUMBENS DECREASED BY PERINATAL COCAINE EXPOSURE
    GIUSTINO, A
    MARSDEN, CA
    BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 : P339 - P339
  • [10] Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter
    Maged M. Harraz
    Prasun Guha
    In Guk Kang
    Evan R. Semenza
    Adarsha P. Malla
    Young Jun Song
    Luke Reilly
    Isaac Treisman
    Pedro Cortés
    Mark A. Coggiano
    Vijayabhaskar Veeravalli
    Rana Rais
    Gianluigi Tanda
    Solomon H. Snyder
    Molecular Psychiatry, 2021, 26 : 370 - 382
12345