EFFECTS OF THE ANTIOXIDANT BUTYLATED HYDROXYANISOLE ON CYTOSOLIC FREE CALCIUM-CONCENTRATION

被引：6
|
作者：
DAVID, M
HORVATH, G
SCHIMKE, I
MUELLER, MM
NAGY, I
机构：
[1] HEIM PAL PEDIAT HOSP,DIV CLIN CHEM,BUDAPEST,HUNGARY
[2] HUMBOLDT UNIV,DEPT CLIN & PATHOL BIOCHEM,O-1086 BERLIN,GERMANY
[3] UNIV VIENNA,DEPT SURG 2,DIV CLIN BIOCHEM,A-1010 VIENNA,AUSTRIA
来源：
TOXICOLOGY | 1993年 / 77卷 / 1-2期
关键词：
BUTYLATED HYDROXYANISOLE (BHA); ANTIOXIDANT; CYTOSOLIC CALCIUM; ENDOTHELIAL CELLS;
D O I：
10.1016/0300-483X(93)90142-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of the antioxidant butylated hydroxyanisole on free intracellular calcium was investigated in rat cardiomyocytes, rat pituitary cells, human umbilical vein endothelial cells, granulocytes and BHK-cells. The effects of incubation time and butylated hydroxyanisole (BHA) concentrations were examined with respect to the extracellular calcium concentration. Butylated hydroxyanisole increased the free cytosolic calcium concentration in a dose- and time-dependent manner irrespective of the presence of extracellular calcium. Differences between all cell types were observed in the sequel of the re-uptake of the calcium ions released by BHA. Dependence on the concentration of extracellular calcium on the extent of sequestration was seen in rat pituitary cells and cardiomyocytes only.
引用
收藏
页码：115 / 121
页数：7
相关论文
共 50 条
  • [1] PLATELET CYTOSOLIC FREE CALCIUM-CONCENTRATION IN PRIMARY HYPERTENSION
    SANG, KHLQ
    BENLIAN, P
    KANAWATI, C
    MONTENAYGARESTIER, T
    MEYER, P
    DEVYNCK, MA
    JOURNAL OF HYPERTENSION, 1985, 3 : S33 - S36
  • [2] PLATELET CYTOSOLIC FREE CALCIUM-CONCENTRATION IN PRIMARY HYPERTENSION
    SANG, KHL
    BENLIAN, P
    DUVAL, C
    MONTENAYGARESTIER, T
    MEYER, P
    DEVYNCK, MA
    ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX, 1985, 78 (11): : 1730 - 1733
  • [3] REGULATION OF CYTOSOLIC FREE CALCIUM-CONCENTRATION BY INTRASYNAPTIC MITOCHONDRIA
    MARTINEZSERRANO, A
    SATRUSTEGUI, J
    MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (02) : 235 - 248
  • [4] PLATELET CYTOSOLIC FREE CALCIUM-CONCENTRATION IN ESSENTIAL-HYPERTENSION
    QUANSANG, KHL
    MONTENAYGARESTIER, T
    DEVYNCK, MA
    NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, 1985, 27 (04): : 279 - 283
  • [5] PLATELET CYTOSOLIC-FREE CALCIUM-CONCENTRATION IN PRIMARY HYPERTENSION
    SANG, KHLQ
    BENLIAN, P
    DUVAL, C
    MONTENAYGARESTIER, T
    MEYER, P
    DEVYNCK, MA
    JOURNAL OF HYPERTENSION, 1985, 3 (05) : 539 - 539
  • [6] CATECHOLAMINE INDUCED INCREASES IN CYTOSOLIC FREE CALCIUM-CONCENTRATION IN HEPATOCYTES
    MURPHY, E
    COLL, KE
    FEDERATION PROCEEDINGS, 1980, 39 (06) : 1927 - 1927
  • [7] EFFECTS OF PROSTAGLANDINS ON THE CYTOSOLIC FREE CALCIUM-CONCENTRATION IN VASCULAR SMOOTH-MUSCLE CELLS
    FUKUO, K
    MORIMOTO, S
    KOH, E
    YUKAWA, S
    TSUCHIYA, H
    IMANAKA, S
    YAMAMOTO, H
    ONISHI, T
    KUMAHARA, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 136 (01) : 247 - 252
  • [8] EFFECTS OF NICARDIPINE ON BLOOD-PRESSURE AND PLATELET CYTOSOLIC FREE CALCIUM-CONCENTRATION IN SHR
    BABA, A
    FUKUDA, K
    KUCHII, M
    HANO, T
    NISHIO, I
    MASUYAMA, Y
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1987, 10 : S70 - S71
  • [9] VASOPRESSIN INCREASES CYTOSOLIC FREE CALCIUM-CONCENTRATION IN GLOMERULAR MESANGIAL CELLS
    BONVENTRE, JV
    SKORECKI, KL
    KREISBERG, JI
    CHEUNG, JY
    AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (01): : F94 - F102
  • [10] PROLACTIN INCREASES CYTOSOLIC FREE CALCIUM-CONCENTRATION IN HEPATOCYTES OF LACTATING RATS
    VILLALBA, M
    ZABALA, MT
    MARTINEZSERRANO, A
    DELACOLINA, R
    SATRUSTEGUI, J
    GARCIARUIZ, JP
    ENDOCRINOLOGY, 1991, 129 (06) : 2857 - 2861
12345