Synthesis, Characterization, Antioxidant and Antimicrobial Activities and DNA Damage of Some Novel 2-[3-alkyl (aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]-phenoxyacetic acids in Human Lymphocytes

被引：0
|
作者：
Ciftci, Esra [1 ]
Beytur, Murat [2 ]
Calapoglu, Mustafa [1 ]
Gursoy-Kol, Ozlem [2 ]
Alkan, Muzaffer [3 ]
Togay, Vehbi Atahan [4 ]
Manap, Sevda [2 ]
Yuksek, Haydar [2 ]
机构：
[1] Suleyman Demirel Univ, Fac Arts & Sci, Dept Chem, TR-32000 Isparta, Turkey
[2] Kafkas Univ, Fac Arts & Sci, Dept Chem, TR-36100 Kars, Turkey
[3] Kafkas Univ, Fac Educ, Primary Sci Educ, TR-36100 Kars, Turkey
[4] Suleyman Demirel Univ, Fac Med, Dept Med Biol, TR-32000 Isparta, Turkey
来源：
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2018年 / 9卷 / 05期
关键词：
1,2,4-triazol-5-one; Antioxidant; Antibacterial; Comet assay;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, nine novel 2-[3-alkyl(aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl] phenoxyacetic acids (2) were obtained by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 2-formylphenoxy acetic acid. Their structures were characterized by using H-1-NMR, C-13-NMR and IR spectral data together with elemental analysis. The synthesized novel compounds were analyzed for their in vitro antioxidant activity methods such as reducing power, free radical scavenging and metal chelating activity. Besides, agar hole methods were used to investigate the antibacterial properties of the 2 type compounds against the strains of B. subtilis, B. cereus, P. aeruginosa, K. Pneumoniae, S. aureus, and E. coli. Finally, the alkaline comet assay was used to investigate genotoxicity potential of the synthesized compounds in the peripheral blood lymphocytes (PBLs).
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收藏
页码：1760 / 1771
页数：12
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