CEPHALOSPORIN-C ACYLASE IN THE AUTOLYSIS OF FILAMENTOUS FUNGI

被引：13

作者：

REYES, F ^{[1
]}

MARTINEZ, MJ ^{[1
]}

ALFONSO, C ^{[1
]}

COPAPATINO, JL ^{[1
]}

SOLIVERI, J ^{[1
]}

机构：

[1] UNIV ALCALA DE HENARES,DEPT MICROBIOL & PARASITOL,ALCALA DE HENARES,SPAIN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb05368.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— Cephalosporin C acylase activity was studied using fluorescamine determination of free — NH2 groups produced in the deacylation of cephalosporin C by the enzyme. Fourteen fungi from different genera were studied and low extracellular cephalosporin C acylase activity was found in the genera Aspergillus, Fusarium and Penicillium. Forty one fungi of these genera were checked but not all presented acylase activity. The enzyme was generally found to be an extracellular enzyme and during the process of autolysis its activity increased with incubation time and with increasing pH of the medium. In no case was β‐lactamase activity detected. Penicillium rugulosum and Penicillium griseofulvum were identified as good cephalosporin C acylase producers. Deacetyl esterase activity was also detected in these fungi. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：128 / 131

页数：4

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