ALZHEIMER AMYLOID PROTEIN-PRECURSOR ENHANCES PROLIFERATION OF NEURAL STEM-CELLS FROM FETAL-RAT BRAIN

被引：59
|
作者：
HAYASHI, Y [1 ]
KASHIWAGI, K [1 ]
OHTA, J [1 ]
NAKAJIMA, M [1 ]
KAWASHIMA, T [1 ]
YOSHIKAWA, K [1 ]
机构：
[1] OSAKA UNIV,INST PROT RES,DIV REGULAT MACROMOLEC FUNCT,SUITA,OSAKA 565,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期
关键词：
D O I：
10.1006/bbrc.1994.2755
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the effect of the Alzheimer amyloid protein precursor (APP) on the proliferation of neural stem cells. Two secretory forms of APP (sAPP770 and sAPP695, with and without the Kunitz-type serine protease inhibitor domain, respectively) were purified from conditioned media of COS-7 cells transfected with genetically modified APP cDNAs. Both secretory APPs promoted the growth of neural stem cells, and the effect of sAPP770 was greater than that of sAPP695. sAPP770 and known growth factors in combination exerted a cooperative stimulation of the stem cell proliferation. These results suggest that APP, especially APP possessing the protease inhibitor domain, regulates the growth of neuronal precursor cells during development of the nervous system. (C) 1994 Academic Press, Inc.
引用
收藏
页码：936 / 943
页数：8
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