ESTABLISHMENT AND CHARACTERIZATION OF PTHRP-PRODUCING HUMAN PANCREATIC-CANCER CELL-LINE

被引：0
|
作者：
NISHI, Y [1 ]
HAJI, M [1 ]
TAKAYANAGI, R [1 ]
IGUCHI, H [1 ]
SHIMAZOE, T [1 ]
HIRATA, J [1 ]
NAWATA, H [1 ]
机构：
[1] NATL KYUSHU CANC CTR,CHEMOTHERAPY DIV RES INST,MINAMI KU,FUKUOKA 815,JAPAN
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1994年 / 5卷 / 01期
关键词：
PANCREATIC CANCER; PARATHYROID HORMONE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-1 in vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.
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页码：33 / 39
页数：7
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