ISOFLURANE ANESTHESIA IS STEREOSELECTIVE

被引：76

作者：

HARRIS, B ^{[1
]}

MOODY, E ^{[1
]}

SKOLNICK, P ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,DEPT ANESTHESIOL & CRIT CARE MED,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 217卷 / 2-3期

关键词：

ISOFLURANE; ANESTHESIA; STEREOISOMERS;

D O I：

10.1016/0014-2999(92)90875-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anesthetic effects of the (+) and (-) isomers of isoflurane were determined in mice. Like the clinically important racemate, both isomers produced dose-dependent increases in anesthetic sleep time. A statistically significant (P < 0.005, ANOVA) difference in the potencies of these isomers ((+) > (-)) was observed. To our knowledge, this is the first demonstration of a stereospecific action of a volatile anesthetic in vivo.

引用

页码：215 / 216

页数：2

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