A GENERAL, ONE-POT METHOD FOR THE SYNTHESIS OF 2-SUBSTITUTED OXAZOLES

被引：23
|
作者：
WILLIAMS, EL
机构：
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 08期
关键词：
OXAZOLE; 2-TRIMETHYLSILYL-1,2,3-TRIAZOLE; ACID CHLORIDE; 1,2,3-TRIAZOLE AMIDE; NITROGEN DISPLACEMENT;
D O I：
10.1016/S0040-4039(00)91852-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2-trimethylsilyl-1,2,3-triazole with acid chlorides readily forms triazole amides. The triazole amides, when heated to 150-degrees-C in sulfolane, rearrange with the elimination of nitrogen to give 2-substituted oxazoles in high yields. The oxazole synthesis is general, and can be carried out in one-pot.
引用
收藏
页码：1033 / 1036
页数：4
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