EFFECTS OF GALLOPAMIL ON ERYTHROCYTE RIGIDITY - RESULTS OF A PILOT-STUDY INVITRO

In 12 patients suffering from cerebro-vascular disease the influence of Gallopamil on membrane-fluidity of erythrocytes was studied. After standardized incubation the blood samples were measured with dosages of 20, 50 and 100-mu-g/ml Gallopamil. For exclusion of dilution effects in a parallel group the same volume of NaCl was added. From a dosage of 50-mu-g up to 100-mu-g a constant trend to improved values could be measured. At 100-mu-g/ml a significant improvement of erythrocytes-rigidity was observed (p = 0.037). The results suggest, that in cerebro-vascular disease Gallopamil does not only have an effect for vasodilation but also for hemorheological parameters in microcirculation.