BRIEF REPORT - PROGNOSTIC IMPORTANCE OF CELLULAR DNA CONTENT IN T1-2 N0 LARYNGEAL SQUAMOUS-CELL CARCINOMAS TREATED WITH RADIOTHERAPY

被引：16
|
作者：
TOFFOLI, G
FRANCHIN, G
BARZAN, L
CERNIGOI, C
CARBONE, A
SULFARO, S
FRANCESCHI, S
BOIOCCHI, M
机构：
[1] CTR RIFERIMENTO ONCOL,DIV EXPTL ONCOL 1,I-33081 AVIANO,ITALY
[2] CTR RIFERIMENTO ONCOL,DIV PATHOL,I-33081 AVIANO,ITALY
[3] CTR RIFERIMENTO ONCOL,DIV EPIDEMIOL,I-33081 AVIANO,ITALY
[4] OSPED CIVILE,DIV RADIOTHERAPY,PORDENONE,ITALY
[5] OSPED CIVILE,DIV OTORHINOLARYNGOL,PORDENONE,ITALY
[6] OSPED CIVILE,DIV PATHOL,PORDENONE,ITALY
来源：
LARYNGOSCOPE | 1995年 / 105卷 / 06期
关键词：
D O I：
10.1288/00005537-199506000-00017
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
One hundred fifty-two unselected, consecutive patients with T1-2N0 laryngeal squamous cell carcinoma received radical radiation therapy at the Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano, Italy. Thirty-one (20.4%) of the patients showed disease recurrence or persistence (R/P) after radiotherapy. Flow-cytometric DNA ploidy measurements were performed in 72 cases; 20 had tumor R/P and 52 did not. Tumor R/P occurred more frequently (in 17 [85%] of 20 cases) in patients with diploid tumors. The hazard ratio of recurrence in diploid tumors as compared with aneuploid tumors, after inclusion of all the other significant prognostic factors in a Cox proportional hazards model, was 8.9 (P<.01). Therefore DNA ploidy seems to be an important marker of tumor R/P in patients with T1-2N0 laryngeal carcinoma after radiotherapy.
引用
收藏
页码：649 / 652
页数：4
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