REPRESSION OF HISTONE H5-GENE EXPRESSION IN CHICKEN MATURE ERYTHROCYTES IS CORRELATED WITH REDUCED DNA-BINDING ACTIVITIES OF TRANSCRIPTION FACTORS SP1 AND GATA-1

被引：10
|
作者：
SUN, JM [1 ]
PENNER, CG [1 ]
DAVIE, JR [1 ]
机构：
[1] UNIV MANITOBA,FAC MED,DEPT BIOCHEM & MOLEC BIOL,770 BANNATYNE AVE,WINNIPEG R3E 0W3,MANITOBA,CANADA
来源：
FEBS LETTERS | 1993年 / 331卷 / 1-2期
关键词：
TRANSCRIPTION; TRANSCRIPTION FACTOR; GENE EXPRESSION; HISTONE H5-GENE;
D O I：
10.1016/0014-5793(93)80313-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During the final stages of erythroid maturation, the expression of the chicken histone H5 gene ceases. The histone H5 promoter has binding sites for Sp1 and UPE-binding protein. The 3' histone H5 enhancer has binding sites for Sp1, GATA-1 and NF1. Here, we show that the DNA-binding activities of transcription factors Sp1 and GATA-1 is reduced 5- to 10-fold in mature cells, while the activities of UPE-binding protein and NF1 remain the same in mature and immature erythrocytes. The reduced activities of Spl and GATA-1 may contribute to the inactivation of the histone H5 gene in mature erythrocytes.
引用
收藏
页码：141 / 144
页数：4
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