SUBSTITUTED 3-OXO-1,25-THIADIAZOLIDINE 1,1-DIOXIDES - A NEW CLASS OF POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE AND CATHEPSIN-G

被引：27

作者：

GROUTAS, WC

KUANG, RZ

VENKATARAMAN, R

机构：

[1] Department of Chemistry, Wichita State University, Wichita

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 198卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been synthesized and their in vitro inhibitory activity toward human leukocyte elastase and cathepsin G was investigated. These compounds were found to inactivate the two enzymes efficiently and in a time-dependent fashion. © 1994 Academic Press, Inc.

引用

页码：341 / 349

页数：9

共 11 条

[1] MECHANISM-BASED ISOCOUMARIN INHIBITORS FOR HUMAN-LEUKOCYTE ELASTASE AND CATHEPSIN-G
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HERNANDEZ, M
GLINSKI, J
KAM, CM
OLEKSYSZYN, J
FEDERATION PROCEEDINGS, 1987, 46 (06) : 2223 - 2223
[2] MECHANISM-BASED INHIBITION OF HUMAN-LEUKOCYTE ELASTASE AND CATHEPSIN-G BY SUBSTITUTED DIHYDROURACILS
GROUTAS, WC
HUANG, H
EPP, JB
VENKATARAMAN, R
MCCLENAHAN, JJ
TAGUSAGAWA, F
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1994, 1227 (03): : 130 - 136
[3] NOVEL POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE AND CATHEPSIN-G - DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE
GROUTAS, WC
CHONG, LS
VENKATARAMAN, R
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (02) : 730 - 739
[4] DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUCCINIMIDE DERIVATIVES AS POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, CATHEPSIN-G AND PROTEINASE-3
GROUTAS, WC
BRUBAKER, MJ
CHONG, LS
VENKATARAMAN, R
HUANG, H
EPP, JB
KUANG, R
HOIDAL, JR
BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (04) : 375 - 381
[5] NEW MECHANISM-BASED SERINE PROTEASE INHIBITORS - INHIBITION OF HUMAN-LEUKOCYTE ELASTASE, PORCINE PANCREATIC ELASTASE, HUMAN-LEUKOCYTE CATHEPSIN-G, AND CHYMOTRYPSIN BY 3-CHLOROISOCOUMARIN AND 3,3-DICHLOROPHTHALIDE
HARPER, JW
HEMMI, K
POWERS, JC
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (21) : 6518 - 6520
[6] A NEW CLASS OF HETEROCYCLIC SERINE PROTEASE INHIBITORS - INHIBITION OF HUMAN-LEUKOCYTE ELASTASE, PORCINE PANCREATIC ELASTASE, CATHEPSIN-G, AND BOVINE CHYMOTRYPSIN-A-ALPHA WITH SUBSTITUTED BENZOXAZINONES, QUINAZOLINES, AND ANTHRANILATES
TESHIMA, T
GRIFFIN, JC
POWERS, JC
JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (09) : 5085 - 5091
[7] THE GABRIEL-COLMAN REARRANGEMENT IN BIOLOGICAL-SYSTEMS - DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PHTHALIMIDE AND SACCHARIN DERIVATIVES AS POTENTIAL MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, CATHEPSIN-G AND PROTEINASE-3
GROUTAS, WC
CHONG, LS
VENKATARAMAN, R
EPP, JB
KUANG, R
HOUSERARCHIELD, N
HOIDAL, JR
BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (02) : 187 - 193
[8] ISOXAZOLINE DERIVATIVES AS POTENTIAL INHIBITORS OF THE PROTEOLYTIC-ENZYMES HUMAN-LEUKOCYTE ELASTASE, CATHEPSIN-G AND PROTEINASE-3 - A STRUCTURE-ACTIVITY RELATIONSHIP STUDY
GROUTAS, WC
VENKATARAMAN, R
CHONG, LS
YODER, JE
EPP, JB
STANGA, MA
KIM, EH
BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (02) : 125 - 128
[9] 2-[(alkylsulfonyl)oxy]-6-substituted-1H-isoindole-1,3(2H)-dione mechanism-based inhibitors of human leukocyte elastase.
Kerrigan, JE
Shirley, JJ
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (04) : 451 - 456
[10] 2-[(sulfonyl)oxy]-6-substituted-1H-isoindole-1,3(2H)-dione mechanism-based inhibitors of human leukocyte elastase.
Shirley, JJ
Kerrigan, JE
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 257 - CHED

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