HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF MORPHINE, MORPHINE-3-GLUCURONIDE, MORPHINE-6-GLUCURONIDE AND CODEINE IN BIOLOGICAL SAMPLES USING MULTIWAVELENGTH FORWARD OPTICAL-DETECTION

被引：50
|
作者：
CHARI, G
GULATI, A
BHAT, R
TEBBETT, IR
机构：
[1] UNIV ILLINOIS,DEPT PHARMACODYNAM,833 S WOOD ST,CHICAGO,IL 60612
[2] UNIV ILLINOIS,DEPT PEDIAT,CHICAGO,IL 60612
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 571卷 / 1-2期
关键词：
D O I：
10.1016/0378-4347(91)80454-K
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An isocratic high-performance liquid chromatographic method has been developed for the determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in plasma, urine and cerebrospinal fluid. The use of an efficient solid-phase extraction procedure together with a forward optical scanning detector allows a detection limit of 500 pg/ml. The method was evaluated by examination of biological samples taken from newborn infants following the intravenous administration of morphine sulfate.
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页码：263 / 270
页数：8
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