NITRIC-OXIDE AS AN ENDOGENOUS MODULATOR OF CHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG AIRWAYS

被引：144
|
作者：
BELVISI, MG
STRETTON, D
BARNES, PJ
机构：
[1] Department of Thoracic Medicine, National Heart and Lung Institute, London, SW3 6LY, Dovehouse Street, Chelsea
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 198卷 / 2-3期
关键词：
NITRIC OXIDE (NO); NONADRENERGIC; NONCHOLINERGIC INHIBITORY (I-NANC) NERVES; CHOLINERGIC NEUROTRANSMISSION; TRACHEA (GUINEA-PIG); (ELECTRICAL FIELD STIMULATION);
D O I：
10.1016/0014-2999(91)90626-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Guinea-pig trachea possesses an inhibitory (bronchodilator) non-adrenergic, non-cholinergic (i-NANC) innervation associated with cholinergic nerves, which may be mediated, at least in part, by nitric oxide (NO). L-N(G)-Nitro-arginine methyl ester (L-NAME), an inhibitor of endogenous NO synthesis, enhanced cholinergic responses to electrical field stimulation with no effect on contractile responses to exogenous acetylcholine or excitatory NANC (e-NANC) bronchoconstriction. The effects of L-NAME were reversed by L-arginine but not D-arginine. These results suggest that NO released by nerve stimulation modulates cholinergic neurotransmission in guinea-pig trachea.
引用
收藏
页码：219 / 221
页数：3
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