PRODUCTION OF DIACYLGLYCEROL AND ARACHIDONIC-ACID IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM PATIENTS WITH ASTHMA AND HEALTHY CONTROLS

被引:0
|
作者
DOOPER, MWSM
TIMMERMANS, A
AALBERS, R
WEERSINK, EJM
DEMONCHY, JGR
KAUFFMAN, HF
机构
[1] UNIV GRONINGEN HOSP,INTERNAL MED CLIN,DEPT ALLERGOL,9713 EZ GRONINGEN 31,NETHERLANDS
[2] UNIV GRONINGEN HOSP,INTERNAL MED CLIN,DEPT PULMONOL,9713 EZ GRONINGEN 31,NETHERLANDS
关键词
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Enhanced activities of peripheral blood cells are a common characteristic of patients with asthma. Objective: Here we tested whether this could be due to a dysfunction in one or more signal transduction systems. Methods: The production of 1,2-diacylglycerol (1,2-DAG) and arachidonic acid was compared in mononuclear blood cells from patients with asthma (n = 10) and healthy controls (n = 12). Results: Using three different stimuli (concanavalin A, aluminium fluoride or the calcium ionophore A23187) no difference in the production of both 1,2-DAG and arachidonic acid could be found between patients and controls before allergen challenge. Concanavalin A-induced 1,2-DAG production could be inhibited completely in the presence of isoprenaline; concanavalin A-induced arachidonic acid production, partially. The inhibitory effect of adenylate cyclase activation on the production of 1,2-DAG and arachidonic acid was identical in patients and controls. Following allergen challenge, there was a tendency to an increased production of 1,2-DAG and arachidonic acid in controls, whereas in patients there was a tendency to a decreased production. Conclusions: Enhanced cellular activities found in patients with asthma are not caused by an intrinsic dysfunction in production of 1,2-DAG and arachidonic acid.
引用
收藏
页码:248 / 254
页数:7
相关论文
共 50 条
  • [1] GLUTATHIONE-PEROXIDASE ACTIVITY AND METABOLISM OF ARACHIDONIC-ACID IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ELDERLY SUBJECTS
    MESKINI, N
    NEMOZ, G
    CHAPUY, P
    HAOND, P
    PAGEAUX, JF
    VERICEL, E
    LAGARDE, M
    PRIGENT, AF
    [J]. CLINICAL SCIENCE, 1993, 85 (02) : 203 - 211
  • [2] THE EFFECT OF DELTA-9-TETRAHYDROCANNABINOL ON ARACHIDONIC-ACID METABOLISM IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS
    DIAZ, S
    SPECTER, S
    VANDERHOEK, JY
    COFFEY, RG
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1994, 268 (03): : 1289 - 1296
  • [3] PRODUCTION OF EOSINOPHIL-ACTIVATING FACTOR (EAF) BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ASTHMA PATIENTS
    THORNE, KJI
    RICHARDSON, BA
    BUTTERWORTH, AE
    HAY, I
    JACKSON, M
    HIGENBOTTAM, TW
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1989, 90 (04): : 345 - 351
  • [4] INCREASED CYTOKINE PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM HEALTHY ELDERLY PEOPLE
    FAGIOLO, U
    COSSARIZZA, A
    SANTACATERINA, S
    ORTOLANI, C
    MONTI, D
    PAGANELLI, R
    FRANCESCHI, C
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 663 : 490 - 493
  • [5] ALTERED ARACHIDONIC-ACID CONTENT IN POLYMORPHONUCLEAR AND MONONUCLEAR-CELLS FROM PATIENTS WITH ALLERGIC RHINITIS AND OR ASTHMA
    ROCKLIN, RE
    THISTLE, L
    GALLANT, L
    MANKU, MS
    HORROBIN, D
    [J]. LIPIDS, 1986, 21 (01) : 17 - 20
  • [6] ARACHIDONIC-ACID METABOLISM BY PERIPHERAL-BLOOD CELLS IN PSORIASIS
    MAURICE, PDL
    ALLEN, BR
    HEPTINSTALL, S
    BATHER, P
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 1984, 111 (06) : 706 - 706
  • [7] ARACHIDONIC-ACID METABOLISM BY PERIPHERAL-BLOOD CELLS IN PSORIASIS
    MAURICE, PDL
    ALLEN, BR
    HEPTINSTALL, S
    BATHER, PC
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 1986, 114 (05) : 553 - 566
  • [8] COLLAGENASE PRODUCTION BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS
    SIMPSON, JW
    MACKLER, BF
    ONEILL, PA
    MAILMAN, ML
    ADAMS, S
    HARRIS, J
    [J]. JOURNAL OF DENTAL RESEARCH, 1978, 57 : 264 - 264
  • [9] IN-VITRO PRODUCTION OF CYTOKINES BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM HYDATID PATIENTS
    RIGANO, R
    PROFUMO, E
    DIFELICE, G
    ORTONA, E
    TEGGI, A
    SIRACUSANO, A
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1995, 99 (03): : 433 - 439
  • [10] INTERLEUKIN-1 PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM LEPROSY PATIENTS
    WATSON, S
    BULLOCK, W
    NELSON, K
    SCHAUF, V
    GELBER, R
    JACOBSON, R
    [J]. INFECTION AND IMMUNITY, 1984, 45 (03) : 787 - 789