CELLULAR ONCOGENES IN HUMAN TERATOCARCINOMA CELL-LINES

被引：15

作者：

TESCH, H

FURBASS, R

CASPER, J

LYONS, J

BARTRAM, CR

SCHMOLL, HJ

BRONSON, DL

机构：

[1] HANOVER MED SCH, HAMATOL KLIN, W-3000 Hannover 61, GERMANY

[2] UNIV ULM, DEPT PEDIAT 1, MOLEC BIOL SECT, W-7900 ULM, GERMANY

[3] SW FDN BIOMED RES, DEPT VIROL & IMMUNOL, SAN ANTONIO, TX 78284 USA

来源：

INTERNATIONAL JOURNAL OF ANDROLOGY | 1990年 / 13卷 / 05期

关键词：

Northern blots; oncogenes; Southern blots; teratocarcinoma cell lines;

D O I：

10.1111/j.1365-2605.1990.tb01046.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

We have analysed, by Northern blots, the expression of 14 cellular oncogenes in nine cell lines established from human teratocarcinomas. All lines expressed considerable amounts of p53, c‐Ki‐ras2, c‐Ha‐ras1, craf1, N‐myc, and c‐fos. Low level expression of c‐myc was detected in some lines. Southern blot experiments revealed no amplification or rearrangement of the c‐Ki‐ras2, N‐myc or c‐fos genes. Using a rapid dot‐blot screening procedure, based on a combination of in‐vitro amplification of ras‐specific sequences and oligonucleotide hybridization, we could detect no activation of Ha‐ras or Ki‐ras or any unexpressed N‐ras sequences secondary to a point mutation at codons 12, 13, or 61. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：377 / 388

页数：12

共 50 条

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[7] ENDOGENOUS RETROVIRUS SEQUENCES EXPRESSED IN HUMAN TERATOCARCINOMA CELL-LINES
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[9] INTERFERON INDUCIBILITY AND SENSITIVITY OF HUMAN TERATOCARCINOMA-DERIVED CELL-LINES
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[10] DIFFERENT PATTERN OF EXPRESSION OF CELLULAR ONCOGENES IN HUMAN NON-SMALL-CELL LUNG-CANCER CELL-LINES
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