EFFECT OF CHRONIC RESTRAINT STRESS ON DENDRITIC SPINES AND EXCRESCENCES OF HIPPOCAMPAL CA3 PYRAMIDAL NEURONS - A QUANTITATIVE STUDY

被引：89
|
作者：
SUNANDA [1 ]
RAO, MS [1 ]
RAJU, TR [1 ]
机构：
[1] NATL INST MENTAL HLTH & NEUROSCI,DEPT NEUROPHYSIOL,BANGALORE 560029,KARNATAKA,INDIA
来源：
BRAIN RESEARCH | 1995年 / 694卷 / 1-2期
关键词：
CHRONIC RESTRAINT STRESS; DENDRITIC SPINE; EXCRESCENCE; HIPPOCAMPUS;
D O I：
10.1016/0006-8993(95)00822-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). The number of excrescences were also markedly increased in stressed rats. The physiological significance and possible mechanism for increased spine density is discussed.
引用
收藏
页码：312 / 317
页数：6
相关论文
共 50 条
  • [1] Dendritic excrescences seem to characterize hippocampal CA3 pyramidal neurons in humans
    M. Lauer
    D. Senitz
    [J]. Journal of Neural Transmission, 2006, 113 : 1469 - 1475
  • [2] Dendritic excrescences seem to characterize hippocampal CA3 pyramidal neurons in humans
    Lauer, M.
    Senitz, D.
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2006, 113 (10) : 1469 - 1475
  • [3] Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress
    Galea, LAM
    McEwen, BS
    Tanapat, P
    Deak, T
    Spencer, RL
    Dhabhar, FS
    [J]. NEUROSCIENCE, 1997, 81 (03) : 689 - 697
  • [4] Variable Dendritic Integration in Hippocampal CA3 Pyramidal Neurons
    Makara, Judit K.
    Magee, Jeffrey C.
    [J]. NEURON, 2013, 80 (06) : 1438 - 1450
  • [5] Calcium dynamics in thorny excrescences of CA3 pyramidal neurons
    Jaffe, DB
    Brown, TH
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1997, 78 (01) : 10 - 18
  • [6] Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews
    Magarinos, AM
    McEwen, BS
    Flugge, G
    Fuchs, E
    [J]. JOURNAL OF NEUROSCIENCE, 1996, 16 (10): : 3534 - 3540
  • [7] Distribution of thorny excrescences on CA3 pyramidal neurons in the rat hippocampus
    Gonzales, RB
    Galvan, CJD
    Rangel, YM
    Claiborne, BJ
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 430 (03) : 357 - 368
  • [8] Stress-induced remodeling of hippocampal CA3 pyramidal neurons
    McEwen, Bruce S.
    [J]. BRAIN RESEARCH, 2016, 1645 : 50 - 54
  • [9] Effects of phenytoin on morphology and structure of hippocampal CA3 pyramidal neurons of rats in chronic stress
    Zhang, YM
    Yang, Q
    Xu, CT
    Li, KS
    Li, WQ
    [J]. ACTA PHARMACOLOGICA SINICA, 2003, 24 (05) : 403 - 407
  • [10] Prenatal Stress Causes Dendritic Atrophy of Pyramidal Neurons in Hippocampal CA3 Region by Glutamate in Offspring Rats
    Jia, Ning
    Yang, Kun
    Sun, Qinru
    Cai, Qing
    Li, Hui
    Cheng, Daxin
    Fan, Xiaoli
    Zhu, Zhongliang
    [J]. DEVELOPMENTAL NEUROBIOLOGY, 2010, 70 (02) : 114 - 125
12345