IGF-I AND PAMIDRONATE INCREASE BONE-MINERAL DENSITY IN OVARIECTOMIZED ADULT-RATS

被引:66
|
作者
AMMANN, P
RIZZOLI, R
MULLER, K
SLOSMAN, D
BONJOUR, JP
机构
[1] UNIV GENEVA, HOP CANTONAL, WORLD HLTH ORG COLLABORATING CTR OSTEOPOROSIS & BO, CH-1211 GENEVA 4, SWITZERLAND
[2] UNIV GENEVA, HOP CANTONAL, DEPT RADIOL, DIV NUCL MED, CH-1211 GENEVA 4, SWITZERLAND
[3] CIBA GEIGY AG, DIV PHARMACEUT, CH-4002 BASEL, SWITZERLAND
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 05期
关键词
OSTEOPOROSIS; BONE MASS; TRABECULAR BONE; CORTICAL BONE; OSTEOCALCIN; OVARIECTOMY; DUAL ENERGY X-RAY ABSORPTIOMETRY;
D O I
10.1152/ajpendo.1993.265.5.E770
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Effects induced by insulin-like growth factor I (IGF-1) and/or the bisphosphonate pamidronate (APD) on bone mineral density (BMD) of the lumbar spine and proximal and midshaft tibia were studied in adult rats made osteopenic by ovariectomy, using dual-energy X-ray absorptiometry. IGF-I, which was administered by osmotic minipumps implanted subcutaneously for 6 wk, caused a dose-dependent increase of BMD at the three investigated sites. A 4-wk course of IGF-I, followed by intermittent cyclical APD administration, induced significant increases of BMD at the levels of spine and proximal tibia. At midshaft tibia, where cortical bone predominates, BMD was increased by IGF-I only. In conclusion, IGF-I increased BMD at sites with trabecular and/or cortical bone, whereas the APD influence was mainly detectable in the former site only.
引用
收藏
页码:E770 / E776
页数:7
相关论文
共 50 条
  • [1] Bone density and shape as determinants of bone strength in IGF-I and/or pamidronate-treated ovariectomized rats
    Ammann, P
    Rizzoli, R
    Meyer, JM
    Bonjour, JP
    OSTEOPOROSIS INTERNATIONAL, 1996, 6 (03) : 219 - 227
  • [2] TREATMENT WITH GROWTH-HORMONE AND IGF-I IN GROWING RATS INCREASES BONE-MINERAL CONTENT BUT NOT BONE-MINERAL DENSITY
    ROSEN, HN
    CHEN, V
    CITTADINI, A
    GREENSPAN, SL
    DOUGLAS, PS
    MOSES, AC
    BEAMER, WG
    JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 (09) : 1352 - 1358
  • [3] LOCALIZATION OF IGF-I IN ADULT-RATS - IMMUNOHISTOCHEMICAL STUDIES
    ANDERSSON, I
    BILLIG, H
    FRYKLUND, L
    HANSSON, HA
    ISAKSSON, O
    ISGAARD, J
    NILSSON, A
    ROZELL, B
    SKOTTNER, A
    STEMME, S
    ACTA PHYSIOLOGICA SCANDINAVICA, 1986, 126 (02): : 311 - 312
  • [5] TREATMENT WITH GROWTH-HORMONE AND IGF-I IN GROWING RATS INCREASES BONE-MINERAL CONTENT BUT NOT BONE-MINERAL DENSITY (VOL 10, PG 1352, 1995)
    ROSEN, HN
    CHEN, V
    CITTADINI, A
    GREENSPAN, SL
    DOUGLAS, PS
    MOSES, AC
    BEAMER, WG
    JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 (11) : 1836 - 1836
  • [6] BONE MECHANICAL-PROPERTIES AND MINERAL DENSITY IN IGF-1-TREATED AND OR PAMIDRONATE-TREATED OVARIECTOMIZED RATS
    AMMANN, P
    RIZZOLI, R
    MEYER, JM
    SLOSMAN, D
    BONJOUR, JP
    JOURNAL OF BONE AND MINERAL RESEARCH, 1993, 8 : S269 - S269
  • [7] ASSESSMENT OF SPINE BONE-MINERAL DENSITY IN OVARIECTOMIZED RATS USING DXA
    YAMAUCHI, H
    KUSHIDA, K
    YAMAZAKI, K
    INOUE, T
    JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 (07) : 1033 - 1039
  • [8] HETEROGENEOUS DECREASE OF BONE-MINERAL DENSITY IN THE VERTEBRAL COLUMN OF OVARIECTOMIZED RATS
    GARCIAMORENO, C
    CALVO, OM
    HERRERO, S
    MARTIN, E
    SUQUIA, B
    SANROMAN, JI
    MARTIN, M
    GARCIATALAVERA, JR
    CALVO, JJ
    DELPINO, J
    BONE, 1995, 16 (04) : S295 - S300
  • [9] IGF-I correlates with bone mineral density in human femoral bone
    Baumgrass, R
    Bogusch, G
    Felsenberg, D
    Gowin, W
    JOURNAL OF BONE AND MINERAL RESEARCH, 1996, 11 : M581 - M581
  • [10] Effect of growth hormone and pamidronate on bone blood flow, bone mineral and IGF-I levels in the rat
    Kapitola, J
    Zák, J
    Lacinová, Z
    Justová, V
    PHYSIOLOGICAL RESEARCH, 2000, 49 : S101 - S106