FRACTURE-HEALING INDUCES EXPRESSION OF THE PROTOONCOGENE C-FOS INVIVO - POSSIBLE INVOLVEMENT OF THE FOS PROTEIN IN OSTEOBLASTIC DIFFERENTIATION

被引：44
|
作者：
OHTA, S
YAMAMURO, T
LEE, K
OKUMURA, H
KASAI, R
HIRAKI, Y
IKEDA, T
IWASAKI, R
KIKUCHI, H
KONISHI, J
SHIGENO, C
机构：
[1] KYOTO UNIV,FAC MED,DEPT NUCL MED & RADIOL,KYOTO 606,JAPAN
[2] OSAKA UNIV,FAC DENT,DEPT BIOCHEM,SUITA,OSAKA 565,JAPAN
来源：
FEBS LETTERS | 1991年 / 284卷 / 01期
关键词：
FRACTURE HEALING; C-FOS; OSTEOBLASTIC DIFFERENTIATION; ALKALINE PHOSPHATASE;
D O I：
10.1016/0014-5793(91)80757-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we report marked in vivo expression of the c-fos gene in the external soft callus (ESC) and periosteal hard callus (PHC) at the fracture site of adult rat tibia. Northern-blot analysis showed that the ESC expressed a high level of c-fos mRNA from post-fracture day 10 to day 28, the time when endochondral ossification progressed, and that the ossifying PHC also expressed c-fos mRNA. This c-fos expression was followed by sequential expression of the genes for alkaline phosphatase, osteopontin and osteocalcin, which are osteoblastic markers. Immunohistochemical analysis showed that the c-Fos protein was predominantly located in osteoblasts in the ossifying calluses.
引用
收藏
页码：42 / 45
页数：4
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