PHARMACOLOGICAL STUDIES ON TERPENOIDS FROM MARINE SPONGES - ANALGESIC AND MUSCLE-RELAXANT EFFECTS

被引：17

作者：

DEPASQUALE, R ^{[1
]}

CIRCOSTA, C ^{[1
]}

OCCHIUTO, F ^{[1
]}

DEROSA, S ^{[1
]}

DESTEFANO, S ^{[1
]}

机构：

[1] CNR,IST CHIM MOLEC INTERESSE BIOL,NAPLES,ITALY

来源：

PHYTOTHERAPY RESEARCH | 1991年 / 5卷 / 02期

关键词：

TERPENOIDS; MARINE SPONGE; ANALGESIA; MUSCLE RELAXANT ACTIVITY;

D O I：

10.1002/ptr.2650050202

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some terpenoids extracted from marine sponge: triacetylated desidein (from Disidea pallescens), 2-tetraprenyl benzoquinol and 4-hydroxy-3-tetraprenylbenzoic acid (from Ircinia muscarum), 2-polyprenyl benzoquinols (from Ircinia spinosula), avarol (from Disidea avara) and furospongin-1 (from Spongia officinalis) were tested by multidimensional Irwin screening and with some tests for analgesic and muscle relaxant activity. The three prenylhydroquinols derivatives and avarol show a good analgesic activity and low toxicity.

引用

页码：49 / 53

页数：5

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