HEMOZOIN DIFFERENTIALLY MODULATES THE PRODUCTION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR IN MURINE MALARIA

被引：0
|
作者：
PRADA, J [1 ]
MALINOWSKI, J [1 ]
MULLER, S [1 ]
BIENZLE, U [1 ]
KREMSNER, PG [1 ]
机构：
[1] HUMBOLDT UNIV BERLIN, INST TROP MED, D-10179 BERLIN, GERMANY
来源：
EUROPEAN CYTOKINE NETWORK | 1995年 / 6卷 / 02期
关键词：
MALARIA PIGMENT; MACROPHAGES; CYTOKINES; BIOASSAYS; NONRADIOACTIVE IN SITU HYBRIDIZATION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When murine peritoneal macrophages were loaded in vitro with Plasmodium vinckei hemozoin and stimulated for 24 hours with interferon-gamma and/or Escherichia coli lipopolysaccharide, the production of interleukin 6 (IL-6) was drastically reduced, whereas the secretion of tumor necrosis factor (TNF) was increased. In addition, non-radioactive in situ hybridizations in spleen sections of P. vinckei infected mice showed more TNF than IL-6 gene expression in the red pulp around hemozoin accumulation. These results provide evidence that IL-6 and TNF are differentially modulated by hemozoin and that subsequently, the secretion of IL-6 seems to be independent of the TNF production during murine malaria.
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收藏
页码：109 / 112
页数：4
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