IDARUBICIN IS ACTIVE ON MDR CELLS - EVALUATION OF DNA-SYNTHESIS INHIBITION ON P388 CELL-LINES

被引：13

作者：

PETRINI, M

MATTII, L

VALENTINI, P

SABBATINI, ARM

GRASSI, B

GRANDI, M

机构：

[1] UNIV PISA,DEPT HEMATOL,I-56100 PISA,ITALY

[2] FARMITALIA CARLO ERBA SPA,RES INST,DEPT EXPTL ONCOL,I-20014 NERVIANO,ITALY

来源：

ANNALS OF HEMATOLOGY | 1993年 / 67卷 / 05期

关键词：

IDARUBICIN; MULTIDRUG RESISTANCE; P-170; LEUKEMIA;

D O I：

10.1007/BF01715052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multidrug resistance is frequently found in patients affected by hematological malignancies and has been related to a poor prognosis of acute leukemia. In the present paper we report results concerning the activity of idarubicin, an anthracycline derivative, on the leukemic P388 and P388 doxorubicin-resistant cell lines. The results clearly show that idarubicin inhibits DNA synthesis in the resistant cell line more actively than doxorubicin.

引用

页码：227 / 230

页数：4

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