Helicobacter pylori - Diagnostic Methods and Therapy

Unconditioned indications to diagnostics and treating of Helicobacter pylori infection are: ulcerative disease, dyspepsia of unknown origin in patients under 45 years of age without other clinical symptoms, MALT lymphangioma of undefined type, status after the endoscopic resection of gastric cancer in early stages and first degree of consanguinity with duffering from gastric cancer. The methods of Helicobacter pylori diagnostics are still evolving. The specificity and sensitivity of diagnostic tests increases. The paper discusses basics and valuation of the invasive studies in Helicobacter pylori diagnostics (biopsy with endoscopic evaluation and DNA, RNA replication with PCR technique from gastric juice) as well as non-invasive ones (urea breath test, serologic researches and PCR application -detecting of the DNA and RNA in stool and saliva). Urea breath test (UBT) has the highest sensitiveness and specificity. In the H. pylori eradication, OAT scheme is most commonly used (14 days of therapy with Omeprazole, Amoxicillin and Tinidasole). Further improvements of the diagnostic methods and standardizing of eradication procedures should effect in better results of preventing and treatment of the infection consequences, particularly that oral cavity may be an ecological niche of the bacteria.