NEW ANTIVIRAL ANTIBIOTICS, CYCLOVIRACIN-B1 AND CYCLOVIRACIN-B2 .1. PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY

被引：33
|
作者：
TSUNAKAWA, M
KOMIYAMA, N
TENMYO, O
TOMITA, K
KAWANO, K
KOTAKE, C
KONISHI, M
OKI, T
机构：
[1] Bristol-Myers Squibb Research Institute, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku
来源：
JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 09期
关键词：
D O I：
10.7164/antibiotics.45.1467
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Kibdelosporangium albatum No. R761-7 (ATCC 55061) produced new antiviral antibiotics, cycloviracins B1 and B2. They show weak activity against Gram-positive bacteria and potent antiviral activity against herpes simplex virus type 1. Unique acylsaccharide structures were established for cycloviracins B1 and B2 by degradation and spectroscopic analysis.
引用
收藏
页码：1467 / 1471
页数：5
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