Spindle Cell Sarcoma of Vagina: A Rare Case Report and Review of Literature

Primary malignancy of the vagina is unusual and sarcoma as the primary is rarer. The majority of sarcomas are diagnosed at an advanced stage. Histopathological grade is the most important factor to predict the outcome. Surgical resection is the main stay of treatment. The role of adjuvant radiotherapy and chemotherapy is controversial. An adjuvant radiotherapy should be given in the case of high-grade tumors, and post-operative surgical margin positive cases. Neoadjuvant chemotherapy should be given in locally advanced cases to decrease the tumor burden to make a possible wide local excision with wider margin. We reported a case of spindle cell sarcoma of the vagina in a 57-year-old woman who was treated with 3 cycles of neoadjuvant chemotherapy followed by surgical resection with adequate margin, and doing well on 6 months follow-up.