HAWORTH MEMORIAL LECTURE - EXPERIMENTS DIRECTED TOWARDS GLYCOCONJUGATE SYNTHESIS

Total synthesis of complex carbohydrates and glycoconjugates are described. Cycloglycosylation was carried out by use of either anomeric fluorides or thioglycosides to obtain cyclodextrins and their analogues. Other targets for synthetic studies have been selected mainly from bio-functional glycoconjugates that include gangliosides, Nod-factors, N- and O-linked glycans of glycoproteins, plant cell wall oligosaccharide acting as endogenous plant hormones, GPI anchor (glycosyl phosphatidylinositol anchor), and functional domains of glycosaminoglycan. Key synthetic transformations in the experiments were highlighted in terms of efficiency and stereoselectivity.