ENHANCEMENT OF HUMAN HERPESVIRUS-6 REPLICATION IN ADULT HUMAN-LYMPHOCYTES BY MONOCLONAL-ANTIBODY TO CD3

被引：14
|
作者：
KIKUTA, H
LU, H
TOMIZAWA, K
MATSUMOTO, S
机构：
[1] Department of Pediatrics, Hokkaido University School of Medicine, sapporo
来源：
JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 06期
关键词：
D O I：
10.1093/infdis/161.6.1085
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-6) replication was assessed in adult peripheral blood mononuclear cells (PBMC) and in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and Southern blot hybridization. Infection ofCBMC by HHV-6 was productive; however, little or no infection was observed with PBMC from adults exposed to the virus even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly enhanced HHV-6 replicative cycles in PBMC from adults. © 1990, University of Chicago. All rights reserved.
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收藏
页码：1085 / 1087
页数：3
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