Central and peripheral manifestations of anti-VGKC antibody-Limbic encephalitis and Morvan's syndrome

Anti-voltage-gated potassium channel antibodies (anti-VGKC) cause hyperexcitability of the peripheral nerve and central nervous system. Morvan's syndrome is characterized by widespread neurological symptoms involving the peripheral nervous system (neuromyotonia), autonomic, and the central nervous system. Limbic encephalitis typically presents with subacute onset of amnesia, behavioral disturbance, psychiatric symptoms, seizures, and altered consciousness. Both Morvan's syndrome and limbic encephalitis have been noted to bear a striking similarity in terms of clinical presentation, association with tumor, and response to immunosuppressive therapy. Both these conditions have been found to be associated with anti-VGKC antibody. Here, we intend to present two cases, one with predominantly peripheral and the other with central manifestation associated with anti-VGKC antibody describing the clinical spectrum of VGKC antibody associated disorders. (C) 2015 Indian Journal of Medical Specialities Trust. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.