A COMPARISON OF VASCULAR BIOLOGICAL ACTIONS OF CARBON-MONOXIDE AND NITRIC-OXIDE

被引：0
|
作者：
LEFER, DJ [1 ]
MA, XL [1 ]
LEFER, AM [1 ]
机构：
[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT PHYSIOL,PHILADELPHIA,PA 19107
来源：
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1993年 / 15卷 / 09期
关键词：
VASODILATION; ENDOTHELIAL PRESERVATION; NEUTROPHIL ADHERENCE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Carbon monoxide (CO) and nitric oxide (NO) were tested in vitro in rat superior mesenteric artery (SMA) rings for vasodilator activity as well as the adherence of cat polymorphonuclear (PMN) leukocytes to isolated cat SMA endothelium. Both CO and NO effectively relaxed rat SMA rings, NO being about 4 times as potent as CO in this regard. Methylene blue, a guanylyl cyclase inhibitor blocked all of the NO relaxation and 75% of the CO-induced relaxation. Also, both CO and NO markedly attenuated adherence of cat PMNs to cat SMA endothelium. NO was about 3 times as potent as CO in this regard. These properties are consistent with potential cytoprotective effects of low concentrations of NO and CO in inflammatory states.
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收藏
页码：617 / 622
页数：6
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