A COMPARISON OF PROPOFOL WITH SEVOFLURANE AND PROPOFOL ALONE FOR INDUCTION AND INTUBATION

STUDY OBJECTIVE: We aimed to study propofol with sevoflurane and propofol alone in evaluating intubating conditions, hemodynamic response during induction and intubation and induction side effects in adult patients undergoing various elective surgical procedures without muscle relaxants. DESIGN: Prospective randomized study. SETTING: Operation theatre of a teaching institute. PATIENTS: The study population consists of 60 ASA I & II, non-obese, adult patients aged between 20-40yrs coming for elective surgical procedures under General Anaesthesia and had Mallampatti class I airway anatomy, 30 of these patients receive propofol alone-"GROUP A" and 30 of who receive propofol with sevoflurane-"GROUP B". MEASUREMENTS AND RESULTS: The heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure before and after induction and post-intubation at 1, 3 and 5 minutes were recorded. Time to induction in seconds (Start of anaesthetic until loss of eye lash reflex), induction side effects like breath holding, cough, excitatory movements, laryngospasm and others (Bradycardia, hypoxia, hyperthermia, hypothermia and injection site pain) were noted. Intubating conditions were better in Group-B than in Group-A, Group-B patients had significantly had more clinically acceptable intubating conditions than Group-A. There was no significant difference in heart rate after induction and intubation between the two groups, except 3min after intubation in Group-A there is significantly low heart rate. There was significant in reduction in systolic blood pressure after induction and intubation in Group-A, however there was no significant difference in diastolic blood pressure and mean arterial pressure between two groups. Induction time is significantly less in Group-A patients when compared to Group-B patients and there was no significant difference in induction side effects between two groups. CONCLUSION: Combination of inhalational 4% sevoflurane with IV propofol 1.5mg/kg is superior to IV propofol 3mg/kg with respect to quality of intubation and less significance with respect to hemodynamic response during induction and intubation in adult patients undergoing various elective surgical procedures without muscle relaxants.