CYTOKINES AND THE TH1/TH2 PARADIGM IN TRANSPLANTATION

被引：207

作者：

NICKERSON, P ^{[1
]}

STEURER, W ^{[1
]}

STEIGER, J ^{[1
]}

ZHENG, XX ^{[1
]}

STEELE, AW ^{[1
]}

STROM, TB ^{[1
]}

机构：

[1] HARVARD UNIV, BETH ISRAEL HOSP, SCH MED, DIV IMMUNOL, BOSTON, MA 02215 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0952-7915(94)90081-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

With studies elucidating the cytokine programs associated with T-cell activation, allograft rejection and tolerance induction, the Th1/Th2 paradigm has became a unifying model to explain the observed cytokine profiles. The proof that these cytokines mediate allograft tolerance, however, is at best indirect. More recent studies highlighting the redundant and pleiotropic nature of cytokine networks suggest that the Th1/Th2 paradigm may not be sufficient to explain fully the mechanisms underlying allograft tolerance.

引用

页码：757 / 764

页数：8

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