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EVALUATION OF NEW ANTIINFECTIVE DRUGS FOR THE TREATMENT OF ACUTE SUPPURATIVE ARTHRITIS IN CHILDREN
被引:3
|作者:
NELSON, JD
NORDEN, C
MADER, JT
CALANDRA, GB
机构:
[1] AMER CYANAMID CO,LEDERLE LABS,DIV MED RES,PEARL RIVER,NY 10965
[2] MARINE BIOMED INST,GALVESTON,TX 77550
[3] MERCK SHARP & DOHME LTD,CLIN RES,W POINT,PA
关键词:
D O I:
10.1093/clind/15.Supplement_1.S172
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Diagnostic criteria for bacterial suppurative arthritis include the demonstration of an inflammatory exudate by aspiration of synovial fluid and the isolation of bacteria from cultures of synovial fluid and/or blood. Clinical manifestations include joint effusion, swelling, tenderness, and pain, with or without redness of the overlying skin. Management consists of antimicrobial therapy, measures designed to relieve symptoms, surgical drainage of infected fluid, and physical therapy. Studies of new anti-infective therapy should be limited to cases of bacterial origin. Prospective, randomized, double-blind or evaluator-blinded, active-control comparative clinical trials should be performed. Clinical response is characterized as success (cure), failure, or indeterminate outcome. The most common successful microbiological outcome is presumptive eradication. Follow-up should continue for 1 year before the final assessment.
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页码:S172 / S176
页数:5
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