ROLE OF RENIN-ANGIOTENSIN SYSTEM IN BLOOD-PRESSURE REGULATION IN PREGNANCY

被引：32
|
作者：
AUGUST, P [1 ]
MUELLER, FB [1 ]
SEALEY, JE [1 ]
EDERSHEIM, TG [1 ]
机构：
[1] CORNELL UNIV,MED CTR,NEW YORK HOSP,CTR CARDIOVASC,DEPT OBSTET & GYNECOL,NEW YORK,NY 10021
来源：
LANCET | 1995年 / 345卷 / 8954期
关键词：
D O I：
10.1016/S0140-6736(95)90012-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We gave captopril (25 mg) to nine pregnant and eight nonpregnant women. From baseline to 60 min post-captopril, mean arterial pressure decreased significantly more in pregnant than in non-pregnant women (mean 15.0 [SE 25] vs 5.2 [1.2] mm Hg; difference 9.8 [95% CI 3.9-1.59] mm Hg, p=0.0036), whereas plasma renin activity increased significantly more in the pregnant group (18.0 [5.5] vs 4.5 [1.9] ng mL(-1) h(-1); difference 13.5 [0.71-26.5], p=0.043). These findings support the hypothesis that stimulation of the renin-angiotensin system in pregnancy maintains blood pressure.
引用
收藏
页码：896 / 897
页数：2
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