The principal aim of management of the Quality of Care is to assure patient satisfaction, through the active involvement of health care staff and the incorporation of strategies, whose main aim is to achieve continuous improvement in clinical activities and to incorporate patient safety as one of its principle components. The management of patient safety is a means to minimizing any possible harm to patients in care processes, including the use of medicines. The principles of patient safety can be applied to both levels of patient care and involve all health care professionals. The risk management is an integral part of patient care. Patient safety depends on the solution of problems and the prevention of errors. The pharmacist's role in patient safety is carried out through Pharmaceutical Care processes and especially through Pharmacotherapy follow-up (PF), which aims to prevent, detect and resolve Drug Therapy Problems (DTP). One of the main difficulties associated with this field is the lack of uniformity of the results obtained throughout the different studies carried out, where differences in definitions occur, as in the classification of drug problems themselves, where process and result are constantly intermingled: Adverse effect, undesirable events, medication errors, DTP, etc. The criteria for classifying such aspects should be uniform, so as to make common information available, which will enable pharmacists to obtain greater knowledge on prevalence, their types, causes, severity and consequences. There is a general desire to improve upon patient safety, to assess the technological processes involved in evaluating effectiveness and safety, and to certify the establishments and health care professionals responsible for such processes. This same approach should also be applied to PF, which is subject to the same basic safety principles. As in the case of all work carried out within the health system, the work of the pharmacist involves the professional and ethical responsibility of making his knowledge, experience and methodology available to his patients. Pharmacists now have the opportunity of making a significant contribution to patient safety, both in general terms and more specifically in the use of medicines, in a field which is currently set for future development.