ANTIGENIC EXPRESSION OF CATHEPSIN-B IN AGED HUMAN BRAIN

被引：46
|
作者：
BERNSTEIN, HG
KIRSCHKE, H
WIEDERANDERS, B
SCHMIDT, D
RINNE, A
机构：
[1] MED ACAD MAGDEBURG,INST ANAT,O-3090 MAGDEBURG,GERMANY
[2] MARTIN LUTHER UNIV,INST BIOCHEM,O-4010 HALLE,GERMANY
[3] DIST HOSP PSYCHIAT,BRANDENBURG,GERMANY
[4] UNIV TROMSO,INST PATHOL,N-9001 TROMSO,NORWAY
来源：
BRAIN RESEARCH BULLETIN | 1990年 / 24卷 / 04期
关键词：
Aging; Alzheimer disease; Cathepsin B; Human brain; Immunohistochemistry;
D O I：
10.1016/0361-9230(90)90157-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The lysosomal thiol proteinase, cathepsin B, has been localized in different regions of aged human brain by use of the peroxidase-antiperoxidase technique. Cathepsin B-immunoreactive material was detected in multiple neurons of human hippocampus, neocortical area A 10, prefrontal gyrus and nuc. basalis of Meynert as well as in single white matter astrocytes. In brains of Alzheimer disease-affected subjects cathepsin B was revealed in neuritic plaques too. Possible functional consequences with regard to normal aging, neuropeptide metabolism and pathological changes are discussed. © 1990.
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页码：543 / 549
页数：7
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