SYNTHESIS OF COMPOUNDS DESIGNED TO INHIBIT BACTERIAL-CELL WALL TRANSGLYCOSYLATION

被引：49

作者：

HECKER, SJ

MINICH, ML

LACKEY, K

机构：

[1] Pfizer Central Research, Groton

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 16期

关键词：

D O I：

10.1021/jo00303a028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methods for preparation of compounds designed to inhibit the transglycosylation step in bacterial cell wall biosynthesis are described. Two hybrid structures (5 and 31) are synthesized, which combine features of the transglycosylase substrate with those of the natural product moenomycin, a known transglycosylation inhibitor. The compounds are synthesized by a convergent route involving the coupling as a phosphate diester of a protected sugar portion with a glycerate—lipid synthon. Details of the syntheses of the sugar and glycerate precursors are discussed. © 1990, American Chemical Society. All rights reserved.

引用

页码：4904 / 4911

页数：8

共 50 条

[1] METHODS FOR SYNTHESIS OF COMPOUNDS DESIGNED TO INHIBIT BACTERIAL-CELL WALL TRANSGLYCOSYLATION
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[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 199 : 362 - ORGN
[2] CONTRIBUTION OF BACTERIAL-CELL WALL COMPOUNDS TO AIRWAY HYPERACTIVITY
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[3] ACTION OF CLOFOCTOL ON BACTERIAL-CELL WALL SYNTHESIS
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[6] BACTERIAL-CELL WALL ISOLATION BY FILTRATION
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[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 498 (01) : 223 - 228
[8] STUDIES ON BACTERIAL-CELL WALL INHIBITORS .9. THE SITE OF INHIBITION OF BACTERIAL-CELL WALL PEPTIDOGLYCAN SYNTHESIS BY AZUREOMYCIN-B, A NEW ANTIBIOTIC
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[9] LYSOLIPIN-1 - NEW INHIBITOR OF BACTERIAL-CELL WALL SYNTHESIS
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