Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles

被引：0
|
作者：
Su, Huaqi [1 ,5 ]
Masters, Colin L. [1 ]
Bush, Ashley I. [1 ]
Barnham, Kevin J. [1 ]
Reid, Gavin E. [2 ,3 ]
Vella, Laura J. [1 ,4 ,5 ]
机构：
[1] Univ Melbourne, The Florey, Parkville, Vic, Australia
[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Sch Chem, Parkville, Vic, Australia
[3] Univ Melbourne, Dept Biochem & Pharmacol, Parkville, Vic, Australia
[4] Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Parkville, Vic, Australia
[5] 30 Royal Parade, Parkville, Vic 3052, Australia
来源：
PROTEOMICS | 2023年
关键词：
Alzheimer's disease; blood; central nervous system; lipids; small extracellular vesicles;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipids play a significant role in maintaining central nervous system (CNS) structure and function, and the dysregulation of lipid metabolism is known to occur in many neurological disorders, including Alzheimer's disease. Here we review what is currently known about lipid dyshomeostasis in Alzheimer's disease. We propose that small extracellular vesicle (sEV) lipids may provide insight into the pathophysiology and progression of Alzheimer's disease. This stems from the recognition that sEV likely contributes to disease pathogenesis, but also an understanding that sEV can serve as a source of potential biomarkers. While the protein and RNA content of sEV in the CNS diseases have been studied extensively, our understanding of the lipidome of sEV in the CNS is still in its infancy.
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页数：21
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