ANTIGENIC STRUCTURE OF THE FOOT-AND-MOUTH-DISEASE VIRUS .6. FUNCTIONAL SITES OF THE IMMUNODOMINANT REGION OF VP1 PROTEIN OF THE FOOT-AND-MOUTH-DISEASE VIRUS O1K AND A22 STRAINS

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GELFANOV, VM
GRECHANINOVA, LA
KAN, ES
YAROV, AV
SUROVOY, AY
VOLPINA, OM
CHEPURKIN, AV
IVANOV, VT
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BIOORGANICHESKAYA KHIMIYA | 1991年 / 17卷 / 05期
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B- and T-epitopes have been localized within the protective fragments of VP1 protein, viz., 136-152 of the O1K strain and 135-159 of the A22 strain of the foot-and-mouth disease virus (FMDV). Antibodies eliciting after immunization of various animals with the 135-159 A22 peptide are directed to different sites of the peptide. Immunogenicity of fragments of the 135-159 A22 peptide on mice correlates with their activity on T-cells of the same animals and protective activity on guinea pigs. The investigations were carried out using synthetic fragments of the 136-152 O1K and 135-159-A22 peptides.
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页码：596 / 605
页数：10
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