Central obesity, metabolic syndrome and type 2 diabetes mellitus

It is well recognized that persons with generalized obesity suffer from a high risk of insulin resistance and its metabolic complications, such as type 2 diabetes mellitus (T2DM), hypertriglyceridemia, low levels of high density lipoprotein cholesterol, hypertension and cardiovascular disease. Accumulation of adipose tissue in a particular anatomical compartment as in abdominal cavity caused an excess risk of insulin resistance until caused metabolic syndrome. Metabolic syndrome, which is defined by a metabolic abnormalities involve a cluster of risk factors of cardiovascular disease is an important risk factor among modern population. Production control of adipocytokine is an important factor of homeostatis glucose and lipid metabolism. Disregulation of adipocytokine production in central obesity has direct pathogenicity of metabolic syndrome. Weight loss or prevention of increased body weight is a good intervention for preventing the obesity, especially central obesity and T2DM. Education about complication of obesity and conscientious involvement by family members is necessary for T2DM treatment.