HIGH-AFFINITY NGF BINDING REQUIRES COEXPRESSION OF THE TRK PROTOONCOGENE AND THE LOW-AFFINITY NGF RECEPTOR

被引：1137
|
作者：
HEMPSTEAD, BL
MARTINZANCA, D
KAPLAN, DR
PARADA, LF
CHAO, MV
机构：
[1] NCI, FREDERICK CANC RES & DEV CTR, MOLEC EMBRYOL GRP, FREDERICK, MD 21701 USA
[2] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, FREDERICK, MD 21701 USA
来源：
NATURE | 1991年 / 350卷 / 6320期
关键词：
D O I：
10.1038/350678a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.
引用
收藏
页码：678 / 683
页数：6
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