APOLIPOPROTEIN-E IN PATIENTS WITH ISCHEMIC-HEART-DISEASE

Contents of lipoprotein E and parameters of lipoprotein metabolism were determined in serum from 78 patients with ischemic heart disease and different variants of lipid metabolism disturbances. Twenty patients had moderately elevated cholesterol levels (5.2 - 6.2 mmol/l) and normal triglycerides (2.3 mmol/l or less), and 58 patients had pronounced hyperlipoproteinemia which in 40 patients could be classified as Fredrickson type 11a, in 14 - type 11b and in 4 - type IV hyperliproproteinemia. In patients with pronounced disturbances of lipid metabolism (with different types of hyperlipoproteinemias) serum apo-E levels were higher than in patients with moderate hypercholesterolemia. No significant correlations were found between serum apoprotein E levels and contents of lipids both in serum and in separate classes of lipoproteins.