COMPLEXATION OF GLUCOSE BY ALPHA-CYCLODEXTRINS AND BETA-CYCLODEXTRINS

The concentration of glucose in aqueous solutions was monitored, using a blood glucose meter, as small weighed cyclodextrin portions were added, Equilibrium constants for the formation of inclusion complexes were calculated. A binding constant determined by this method has been verified by a technique involving competition of the guest with methyl orange indicator dye. Delta H-0 values for the reactions were estimated using calorimetry. These values along with Delta G(0) provided estimates of the standard entropies. The values calculated compare favorably with those from a previously determined empirical equation. The possibility of hydrogen bond formation is suggested by the large negative enthalpies as well as by molecular mechanics calculations.