SOLUBLE CD4 AND CD8 IN THE PERIPHERAL-BLOOD OF PATIENTS WITH MULTIPLE-SCLEROSIS AND HTLV-1-ASSOCIATED MYELOPATHY

被引：13

作者：

TSUKADA, N ^{[1
]}

MATSUDA, M ^{[1
]}

MIYAGI, K ^{[1
]}

YANAGISAWA, N ^{[1
]}

机构：

[1] SHINSHU UNIV,SCH MED,DEPT NEUROL,MATSUMOTO,NAGANO 390,JAPAN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 35卷 / 1-3期

关键词：

SOLUBLE CD4; SOLUBLE CD8; ENZYME-LINKED IMMUNOSORBENT ASSAY; MULTIPLE SCLEROSIS; HUMAN-T-LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1)-ASSOCIATED MYELOPATHY (HAM);

D O I：

10.1016/0165-5728(91)90182-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the presence of soluble (s) CD4 and sCD8, released from activated T cells, in the sera of patients with multiple sclerosis (MS) and human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). In addition, peripheral blood T cell subsets in patients with MS and HAM were analyzed by single and two color flow cytometry. The serum level of sCD8 was significantly elevated in MS patients as compared with controls (p < 0.001). Sera from patients with an exacerbation of acute relapsing MS showed a higher sCD8 level than the patients in remission or controls (p < 0.01 and p < 0.001, respectively). The serum levels of both sCD4 and sCD8 were also significantly elevated in patients with HAM (p < 0.001 and p < 0.001, respectively). In addition, a significantly increased serum level of soluble interleukin-2 receptor (sIL-2R) was found in patients with HAM as compared with that of controls (p < 0.001). These observations suggest that CD8 cells may be activated in the peripheral blood of patients with MS and sCD8 may be related to clinical activity, but that both CD4 and CD8 cells may be activated in the peripheral blood of patients with

引用

页码：285 / 293

页数：9

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