SODIUM DEOXYCHOLATE EXERTS A DIRECT DESTRUCTIVE EFFECT ON HIV AND INFLUENZA-VIRUSES IN-VITRO AND INHIBITS RETROVIRUS-INDUCED PATHOLOGY IN AN ANIMAL-MODEL

被引：5

作者：

OXFORD, JS ^{[1
]}

ZUCKERMAN, MA ^{[1
]}

RACE, E ^{[1
]}

DOURMASHKIN, R ^{[1
]}

BROADHURST, K ^{[1
]}

SUTTON, PM ^{[1
]}

机构：

[1] PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,SALISBURY SP4 0JG,WILTS,ENGLAND

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1994年 / 5卷 / 03期

关键词：

D O I：

10.1177/095632029400500306

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bile salt sodium deoxycholate had a virucidal effect on influenza, Rauscher leukaemia and HIV-1 viruses, reducing virus infectivity by a maximum of 6 logs TCID50 ml(-1) after 1 h incubation at 37 degrees C with 50 mu g ml(-1) of the compound. Electron microscopy demonstrated directly that sodium deoxycholate and other bile salts perturbed influenza virus structure causing partial or complete disruption of the virion lipid membrane, thus allowing entry of phosphotungstate dye to the virion interior. Parenteral administration of sodium deoxycholate (14mg kg(-1)) to Balb/C mice abrogated pathology caused by Rauscher leukaemia virus replicating in the spleen and influenza virus replicating in the lung. Bile salts may also have clinical potential as topical virucidal agents at the point of entry of enveloped viruses and particularly against HIV.

引用

页码：176 / 181

页数：6