SESQUILIGNAN HAEDOXANS - INTERACTION WITH THE GABA(A) RECEPTOR IN RAT-BRAIN

被引：5
|
作者：
OZOE, Y
HASEGAWA, H
MOCHIDA, K
SATOH, H
IWABUCHI, J
KUROZUMI, A
TANIGUCHI, E
机构：
[1] NIPPON KAYAKU CO LTD, DIV AGROCHEM, AGEO RES LABS, AGEO, SAITAMA 362, JAPAN
[2] KYUSHU UNIV, FAC AGR, DEPT AGR CHEM, FUKUOKA 812, JAPAN
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 04期
关键词：
D O I：
10.1271/bbb.58.760
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(+)-Haedoxan A, an insecticidal sesquilignan, inhibited the specific binding of the noncompetitive GABA antagonist [S-35]t- butylbicyclophosphorothionate (TBPS) to rat brain membranes in concentration-dependent and noncompetitive manners. The data show haedoxan's interaction with a site coupled to the TBPS-binding site on the GABA(A) receptor in rat brain, while the physiological significance of the interaction remains to be discovered.
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页码：760 / 761
页数：2
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